I'm still pregnant as I write this, but let me tell you about my experience with ZeroTaboos’ Juicy Balance Serum just two months ago.
While we were finishing testing our Juicy Balance formula, I was 19 weeks pregnant and had some bothersome (though nothing too alarming) symptoms of yeast overgrowth: a bit too much discharge and some irritation. Pretty typical for pregnancy, as they say.
Why not Clotrimazole for yeast during pregnancy?
I wanted to avoid Clotrimazole while pregnant. According to clinical studies, less than 10% of clotrimazole ends up in the bloodstream, but I’d still prefer not to use those messy creams for a whole week. Hear me out.
Oral azoles, like fluconazole, are extremely toxic for the fetus — even a single dose can be harmful.
And if you’ve ever been pregnant, you know the FDA’s logic with another mainstream chemical: retinoids. You are told to stop all of them during pregnancy, both oral and topical. That’s because oral retinoids are proven teratogens, but even with topical tretinoin, where absorption is less than 2% and concentrations are tiny (less than 0.025%), the FDA still says stop — out of an abundance of caution.
So why don’t we apply the same logic to the azole family? A single dose of vaginal clotrimazole can range from 0.5 g to 5 g, and 10% of that may end up in your bloodstream. Use it for 7–14 days, and it’s considered fine? Let me know your thoughts in the comments — I want to understand what I might be missing.
Call me cautious (or paranoid), but I’m personally not cool with that.
Why not other zerotaboos formulas?
Our Fresh Balance Serum would have been a great option for mild yeast symptoms (the “something is off” kind, not pathological), since it contains boric acid. But boric acid is a known fetal toxin, so I couldn’t use it during pregnancy.
I could have also used our Fast Probiotics with lactoferrin, which I’d already tested on myself and with customers last year (amazing results!). But I wanted to challenge the new formula in a situation where my vaginal health was clearly compromised.
So, I reached for Juicy Balance. It doubles as a lubricant — something many customers have asked for. I wanted a true multitasker: slip and glide without the mess, and a formula that actually improves vaginal microbiome health instead of disrupting it like most lubricants on the market.
Since I was definitely in a compromised vaginal state — with obvious symptoms (a rarity for me) — I figured, why not put Juicy Balance to the test?
Why I risk it with Juicy Balance while pregnant
Did we have human studies on pregnant women? Nope. We’re a tiny startup.
Was I worried about any of the ingredients harming my baby? Also no. Here’s why:
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Lactoferrin: studied extensively both orally and intravaginally in pregnant women. It’s extremely beneficial in pregnancy in any form. I even add a spoonful to my protein shake daily.
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Xylitol: intravaginal use hasn’t been studied much, but oral xylitol has. In fact, studies show it reduces mother-to-child transmission of cavity-causing bacteria. I already use it daily in gum and toothpaste (about 1 g orally per day).
About xylitol absorption:
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The vaginal mucosa can absorb small molecules, especially lipophilic ones.
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Xylitol, however, is hydrophilic — it mostly stays local, with minimal systemic absorption expected.
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Oral cavity studies show most xylitol is swallowed and metabolized in the gut, not absorbed through mucosa. That suggests intravaginal xylitol primarily acts locally (anti-adhesion, anti-biofilm) rather than systemically.
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Even high oral doses (5–7 g/day) were safe for pregnant women and effective in normalizing both their own and their babies’ oral microbiome.
The rest of the ingredients? Pretty inert.
📊 The First Test: May 26, 2025
Before starting a 5-day regimen of Juicy Balance, I used a Juno Bio vaginal microbiome kit for a baseline. Collecting the sample was easy — same as a Covid test, just a swab in the vagina instead of the nose.
I shipped it off and started my Juicy Balance routine: nightly, about 1 g applied intravaginally with a small syringe. This is about the same amount someone might use if applying it as a lubricant.
The first night I felt a bit of tingling — not burning, but noticeable. I knew this would pass as my pH rebalanced. With any water-based lubricant, if your vaginal pH is off, an acidic product can trigger tingling or even burning. That’s why you should always proceed slowly, stop if you feel discomfort, and try again when your flora has stabilized.
By the second night, applications were comfortable, likely because my pH had started moving back toward normal.
Baseline Results: Before using the product
My results showed a Type 1 microbiome, dominated by Lactobacillus crispatus — one of the most protective bacteria we can have. That part was good. But when I looked closer, things weren’t so comforting:
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Protective bacteria (Lactobacillus): ~75%
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Disruptive anaerobes: ~25%
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Ureaplasma parvum: a hefty 23% (that’s high)
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Candida albicans: 100% of the fungal load
For anyone not familiar, here’s what that meant in plain terms:
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Lactobacillus crispatus is like a shield. It produces lactic acid that keeps the vaginal pH low and makes it hard for harmful microbes to grow.
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Ureaplasma parvum isn’t always a problem, but in pregnancy, high levels can be linked to risks like preterm birth.
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Candida albicans is the yeast most women recognize — the culprit behind yeast infections.
So even though my results showed protection, I also had clear red flags.
🌱 The Second Test: June 3, 2025
Just a week later (I waited a day after I tried my new formula for five days) , I repeated the test. And the results surprised even me:
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Protective bacteria: ↑ to 92%
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Ureaplasma: ↓ down to just 6%
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Anaerobes: dropped to 7%
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Candida albicans: still present, but this time flagged as “normal unless symptoms are present.”
That shift was dramatic. My shield of Lactobacillus had strengthened, and the disruptive bacteria had nearly disappeared.
🧪 Breaking Down the Ingredients (and Why They Worked)
Here’s what’s inside My Juicy Balance and how I believe each piece contributed:
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Water – Sounds simple, but water makes the base light, non-staining, and compatible with the body. It ensures everything spreads evenly.
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NaCl – A touch of salt helps create a gentle osmotic effect, drawing excess fluid from tissues and keeping the environment balanced.
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Xylitol – This natural sugar alcohol doesn’t feed yeast, but it does block harmful bacteria from sticking to cells. It may have helped keep Ureaplasma and other anaerobes from hanging on.
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Gluconolactone – Slowly lowers the pH to 4.7–4.9 over 12 hours, which is the sweet spot for vaginal health. A balanced acidic pH favors Lactobacillus and discourages troublemakers.
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Lactoferrin – A protein found in human secretions, it binds iron (which bacteria need to grow) and has antimicrobial, antiviral, and anti-inflammatory properties. I believe this was a key factor in shifting my flora.
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HEC (Hydroxyethylcellulose) – A natural thickener that gives the serum a smooth gel feel, making it easy to apply without dripping.
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Carrageenan – Derived from seaweed, this adds slipperiness and moisture. It’s not only soothing but also makes the product an excellent lubricant.
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Potassium Sorbate & Sodium Benzoate – Mild preservatives that keep the formula safe without disrupting good bacteria.
👉 Why it works as a lubricant
The combo of water + HEC + carrageenan creates a hydrating, non-sticky gel that mimics natural lubrication. It’s safe, gentle, and enhances comfort — all while supporting the microbiome.
🤰 Why This Matters in Pregnancy
Pregnancy isn’t just about growing a baby — it’s about keeping the vaginal environment stable. Here’s why each microorganism mattered for me at this stage:
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Lactobacillus: Protects against infections that could trigger preterm labor. The higher the better.
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Ureaplasma: High levels have been linked to complications in some studies. Seeing it drop was a relief.
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Candida: Tricky. It can cause discomfort and infections, but sometimes it’s present without symptoms. The fact that my protective bacteria rose may help keep it in check.
👉 Why pH matters
In pregnancy, a healthy acidic pH is even more crucial. It’s like locking the door against microbes that shouldn’t be there. Ingredients like gluconolactone helped me maintain this balance naturally.
🌸 Lactoferrin: The Bigger Picture for a Bigger Belly
I feel genuinely proud of how this formula performed. Of course, every pregnancy is unique, and what worked for me may not work for everyone.
Still, if you’re pregnant and hesitant about intravaginal products, consider lactoferrin in other forms, like oral supplements. It has proven benefits for both microbiome balance and iron metabolism (improving hemoglobin and ferritin, with fewer side effects than iron salts).
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Antimicrobial & pro-Lactobacillus: LF binds iron (which many pathogens need), shows activity against BV-associated bacteria, and is associated with increases in Lactobacillus after vaginal use. PubMed Central
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Anti-inflammatory / pro-homeostasis: Intravaginal LF reduced oxidative stress markers in amniotic fluid (pilot RCT) and modulated inflammatory mediators (PGE₂, MMPs) after amniocentesis. These effects could be relevant to lowering pregnancy-related inflammatory risk. PubMed+1
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Clinical signals for BV/VVC prevention: Trials using LF (often paired with Lactobacillus) show reduced recurrence of bacterial vaginosis and recurrent vulvovaginal candidiasis, and case series suggest benefit in women at risk for preterm delivery (hypothesis-generating, not definitive). PubMed+2PubMed+2PubMed Central
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Pregnant women with iron deficiency anemia received oral bovine lactoferrin 100 mg twice daily vs ferrous sulfate. Results: LF improved Hb and ferritin as effectively as iron salts, with fewer GI side effects.
Key take-home: Among non-drug options, vaginal lactoferrin has human pregnancy data showing biochemical improvements (oxidative stress, inflammatory markers) and microbiome shifts toward Lactobacillus, plus BV/VVC maintenance data (often with probiotics) and it improves your hemoglobin and ferritin.
💬 Final Thoughts
At 29 weeks, I feel stronger knowing my microbiome is more resilient. My Juicy Balance wasn’t just soothing — it seemed to give my protective bacteria a real advantage. And the fact that it’s water-based, non-staining, and usable as a lubricant made the whole experience simple and stress-free.
Also, if you'd like to see my actual reports from Juno Bio: the kind you can get if you participate in our giveaway, here they are: